Journal

The AEVIOM Journal

The science of cellular longevity, explained without shortcuts: mechanisms, studies, sources.

Le NAD+ : pourquoi votre énergie cellulaire s'effondre après 40 ans
Longevity Science

NAD+: Why Your Cellular Energy Collapses After 40

NAD+ governs more than 500 biological reactions. Its decline after 40 is one of the best-documented aging mechanisms in contemporary geroscience.

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Longevity Science The Epigenetic Clock: Can Science Really Measure Your Biological Age? Since Steve Horvath in 2013, science can measure real biological age through DNA methylation. The Horvath clock, GrimAge, DunedinPACE, and their link... Longevity Science Zombie Cells: How Cellular Senescence and Inflammaging Accelerate Aging Cells that refuse to die secrete a pro-inflammatory cocktail that poisons tissue. Cellular senescence, SASP and inflammaging explained by geroscience. Longevity Science Why Women Live Longer: The Cell Biology of Sex-Based Aging The X chromosome, maternal mitochondria, menopause and the epigenome, sex-based immunosenescence: cell biology explains why men and women age differently. Longevity Science Gut Microbiome and Longevity: What Centenarians Have in Common The gut microbiome is a 1-2 kg organ whose composition governs inflammation, immunity and longevity. Akkermansia muciniphila, dysbiosis, urolithin A. Longevity Science The Circadian Clock and Aging: Why Your Biological Rhythm Shapes Longevity 2017 Nobel Prize: circadian clock disruption with age affects sleep, metabolism and immunity, through a direct link to NAD+ and the sirtuins... Longevity Science What the World's Oldest Animals Teach Us About the Biology of Longevity A 200-year-old bowhead whale, the naked mole-rat, a 400-year-old Greenland shark, the tardigrade, the immortal jellyfish: what the longest-lived animals teach geroscience. Longevity Science The Blue Zones: What the World's Longest-Living Populations Teach Us About the Biology of Aging Sardinia, Okinawa, Loma Linda, Nicoya, Ikaria: five populations that, without modern medicine, solved part of biological aging. What geroscience takes from them. Longevity Science NAD+ and Coenzyme Q10: Why These Two Molecules Are Complementary in Mitochondrial Biology NAD+ and CoQ10 operate at consecutive steps of the mitochondrial respiratory chain. Their parallel decline with age partly explains the energy collapse... Longevity Science The Longevity Hotel: When Luxury Becomes a Biological Intervention Clinique La Prairie, Lanserhof, Büchinger Wilhelmi, SHA Wellness: these establishments measure your biological age and build protocols around the Hallmarks of Aging.... Longevity Science 5 Habits That Accelerate Biological Aging Genetics accounts for only 20-30% of biological longevity. Five daily habits measurably accelerate cellular aging — here are the mechanisms documented by... Longevity Science Exercise and Cellular Aging: What Biology Really Says Exercise is the best-documented longevity intervention in medicine. Cell biology has decoded its precise mechanisms, from NAD+ to telomeres, mitochondria to the... Longevity Science Mitochondria and Aging: Why Your Cellular Energy Output Declines After 40 Mitochondrial dysfunction is one of the best-documented mechanisms of biological aging. Understanding why your mitochondria lose efficiency means understanding the fatigue that... Longevity Science The Hallmarks of Aging: The Scientific Framework That Unified Aging Biology In 2013 and again in 2023, López-Otín et al. laid out in Cell the reference framework for cellular aging: twelve mechanisms, three...